The LCMS-8040 was designed to provide significantly higher sensitivity while maintaining the high speed offered by the LCMS-8030. Ultrafast MRM transition speeds, up to 555 MRMs per second (dwell times of 1 msec and pause times of 1 msec) are achieved. In addition, the LCMS-8040 features the polarity switching at 15 msec and high speed scanning rate of 15. 000 usec. By incorporating newly improved ion optics UF-Lens and UFsweeper II collision cell technology, the LCMS-8040 provides higher multiple reaction monitoring (MRM) sensitivity. This higher sensitivity expands the potential range of LCMSMS applications.